Enhanced Synchrony in the Primary Motor Cortex of Mptp Primates May Underlie Muscle Co-Contraction and Rigidity

摘要: The normal activation of muscles is highly compromised in Parkinson’s disease (PD). Antagonistic tend to co—contract during movement (Wiesendanger and Ruegg, 1978), while are rigid at rest (Selby, 1990). Two (non mutually exclusive) peripheral mechanisms have been suggested underlie these symptoms: (a) increased excitability spinal motor units (Cantello et al., 1995), (b) abnormal reciprocal inhibition the cord (Bathien Rondot, 1977; Hayashi 1988; Lelli 1991; Delwaide 1996; Meunier 2000). However, both hypotheses still under debate. Moreover, some studies argued that cortico-motor neuron transmission largely unchanged PD (Dick 1984). This implies, as widely accepted, source for rigidity lies mainly within central nervous system (CNS) upstream from cord. question where?