Production of colony-stimulating factor by leukemic leukocytes.

摘要: The production of colony-stimulating factor (CSF) by the peripheral blood cells untreated patients with acute myeloid leukemia (AML) was measured in agar culture system using normal human bone marrow as source colony-forming units (CFUc). CSF found to be variable and related morphologic subtype AML--cells from monocytic produced or large quantities CSF, while (with one exception) those myeloblastic little no CSF. There a general relationship between serum lysozyme levels. Attempts demonstrate consistent inhibitory effect exerted leukemic on leukopoiesis vitro were negative. Results instead suggested that addition feeder layer could raise levels above obtained leukocytes alone, possibly recruiting additional CFUc marrow.