Nuclear Receptors in Lipid Metabolism: Targeting the Heart of Dyslipidemia
作者： Simon W. Beaven , Peter Tontonoz
DOI: 10.1146/ANNUREV.MED.57.121304.131428
关键词:
摘要: Dyslipidemia is the sine qua non of atherosclerosis, but it also strongly associated with metabolic syndrome, obesity, diabetes, and fatty liver disease. The molecular basis for future therapies requires understanding pivotal role nuclear hormone receptors in lipid inflammatory homeostasis. This review summarizes evidence that X receptor (LXR) peroxisome proliferator-activated (PPAR) are key transcriptional regulators metabolism. Additionally, their effects on glucose homeostasis inflammation make LXR PPAR signaling networks attractive targets managing lipid-related diseases.
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