Method for selectively inhibiting acat1 in the treatment of neurodegenerative diseases
作者： Yohei Shibuya , Zhaoyang Niu , Ta-Yuan Chang , Catherine C. Y. Chang
DOI:
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摘要: The present invention features methods for stimulating clearance of misfolded or aggregated proteins peptides in microglia neurons, and treating neurodegenerative diseases associated with such pathology brain by selectively inhibiting the expression activity Acyl-CoA:Cholesterol Acyltransferase 1, but not 2.
lens.org参考文章(66)
Frédéric Lafaye, Eric Nicollet, System for deploying software components on computation units that are limited in terms of processing capacity ,(2008)
Elena Bryleva, Yohei Shibuya, Ta-Yuan Chang, Maximillian A. Rogers, Catherine C. Y. Chang, Stephanie Murphy, Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease ,(2013)
Elena Bryleva, Ta-Yuan Chang, Maximillian A. Rogers, Catherine C.Y. Chang, Stephanie Murphy, Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease ,(2013)
Kim Ornvold, Stephen C. Strom, André Delhon, Jean-François Patoiseau, Randeep Kashyap, Ellen T. Chang, Ta Yuan Chang, Robert V. Farese, Catherine C.Y. Chang, John J. Fung, Ruhong Dong, Song Lin, Chi-Yu Gregory Lee, Naomi Sakashita, Oneil Lee, Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine Journal of Biological Chemistry. ,vol. 275, pp. 28083- 28092 ,(2000) , 10.1074/JBC.M003927200
I Tabas, A R Tall, D A Weiland, Inhibition of acyl coenzyme A:cholesterol acyl transferase in J774 macrophages enhances down-regulation of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase and prevents low density lipoprotein-induced cholesterol accumulation Journal of Biological Chemistry. ,vol. 261, pp. 3147- 3155 ,(1986) , 10.1016/S0021-9258(17)35761-7
Eric A. Schon, Estela Area-Gomez, Michael P. Yaffe, Methods for diagnosis and treatment of neurodegenerative diseases or disorders ,(2011)
CL Wellington, Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism. Clinical Genetics. ,vol. 66, pp. 1- 16 ,(2004) , 10.1111/J.0009-9163.2004.00280.X
Luigi Puglielli, Rudolph Tanzi, Matthew Frosch, Dora Kovacs, Methods for treating ACAT-related diseases ,(2004)
Traian V Chirila, Piroska E Rakoczy, Kerryn L Garrett, Xia Lou, Ian J Constable, The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials. ,vol. 23, pp. 321- 342 ,(2002) , 10.1016/S0142-9612(01)00125-9
C. Settembre, C. Di Malta, V. A. Polito, M. G. Arencibia, F. Vetrini, S. Erdin, S. U. Erdin, T. Huynh, D. Medina, P. Colella, M. Sardiello, D. C. Rubinsztein, A. Ballabio, TFEB links autophagy to lysosomal biogenesis. Science. ,vol. 332, pp. 1429- 1433 ,(2011) , 10.1126/SCIENCE.1204592