Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease
作者： Elena Bryleva , Yohei Shibuya , Ta-Yuan Chang , Maximillian A. Rogers , Catherine C. Y. Chang
DOI:
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摘要: The present invention features methods for stimulating clearance of amyloid beta in microglia, decreasing cognitive decline associated with pathology, and treating Alzheimer's disease by selectively inhibiting the expression or activity Acyl-CoA:Cholesterol Acyltransferase 1, but not 2.
lens.org 参考文章(34)
Samira Lakhal-Littleton, Matthew Wood, Exosomes for Delivery of Biotherapeutics ,(2012)
Pieter Jaap Gaillard, Albertus Gerrit De Boer, Arjen Brink, Methods and compositions for targeting agents into and across the blood-brain barrier and other endothelial cell microvascular barriers ,(2011)
Elena Bryleva, Ta-Yuan Chang, Maximillian A. Rogers, Catherine C.Y. Chang, Stephanie Murphy, Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease ,(2013)
Kim Ornvold, Stephen C. Strom, André Delhon, Jean-François Patoiseau, Randeep Kashyap, Ellen T. Chang, Ta Yuan Chang, Robert V. Farese, Catherine C.Y. Chang, John J. Fung, Ruhong Dong, Song Lin, Chi-Yu Gregory Lee, Naomi Sakashita, Oneil Lee, Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine Journal of Biological Chemistry. ,vol. 275, pp. 28083- 28092 ,(2000) , 10.1074/JBC.M003927200
I Tabas, A R Tall, D A Weiland, Inhibition of acyl coenzyme A:cholesterol acyl transferase in J774 macrophages enhances down-regulation of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase and prevents low density lipoprotein-induced cholesterol accumulation Journal of Biological Chemistry. ,vol. 261, pp. 3147- 3155 ,(1986) , 10.1016/S0021-9258(17)35761-7
Francesco Bellini, Francine Gervais, Therapeutic formulations for the treatment of beta-amyloid related diseases ,(2003)
Luigi Puglielli, Rudolph Tanzi, Matthew Frosch, Dora Kovacs, Methods for treating ACAT-related diseases ,(2004)
Traian V Chirila, Piroska E Rakoczy, Kerryn L Garrett, Xia Lou, Ian J Constable, The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials. ,vol. 23, pp. 321- 342 ,(2002) , 10.1016/S0142-9612(01)00125-9
Alessio Peracchi, Prospects for antiviral ribozymes and deoxyribozymes. Reviews in Medical Virology. ,vol. 14, pp. 47- 64 ,(2004) , 10.1002/RMV.415
M. Giovannoni, V. Piaz, C. Vergelli, D. Barlocco, Selective ACAT Inhibitors as Promising Antihyperlipidemic, Antiatherosclerotic and Anti-Alzheimer Drugs Mini-reviews in Medicinal Chemistry. ,vol. 3, pp. 576- 584 ,(2003) , 10.2174/1389557033487890