Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease

作者: Elena Bryleva , Ta-Yuan Chang , Maximillian A. Rogers , Catherine C.Y. Chang , Stephanie Murphy

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摘要: The present invention features methods for decreasing the size and density of amyloid plaques, cognitive decline associated with pathology, treating Alzheimer's disease by selectively inhibiting activity Acyl-CoA:Cholesterol Acyltransferase 1, but not 2.

参考文章(29)
Kim Ornvold, Stephen C. Strom, André Delhon, Jean-François Patoiseau, Randeep Kashyap, Ellen T. Chang, Ta Yuan Chang, Robert V. Farese, Catherine C.Y. Chang, John J. Fung, Ruhong Dong, Song Lin, Chi-Yu Gregory Lee, Naomi Sakashita, Oneil Lee, Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine Journal of Biological Chemistry. ,vol. 275, pp. 28083- 28092 ,(2000) , 10.1074/JBC.M003927200
Luigi Puglielli, Rudolph Tanzi, Matthew Frosch, Dora Kovacs, Methods for treating ACAT-related diseases ,(2004)
Traian V Chirila, Piroska E Rakoczy, Kerryn L Garrett, Xia Lou, Ian J Constable, The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials. ,vol. 23, pp. 321- 342 ,(2002) , 10.1016/S0142-9612(01)00125-9
Alessio Peracchi, Prospects for antiviral ribozymes and deoxyribozymes. Reviews in Medical Virology. ,vol. 14, pp. 47- 64 ,(2004) , 10.1002/RMV.415
M. Giovannoni, V. Piaz, C. Vergelli, D. Barlocco, Selective ACAT Inhibitors as Promising Antihyperlipidemic, Antiatherosclerotic and Anti-Alzheimer Drugs Mini-reviews in Medicinal Chemistry. ,vol. 3, pp. 576- 584 ,(2003) , 10.2174/1389557033487890
Mami Ikenoya, Yasunobu Yoshinaka, Hideyuki Kobayashi, Katsumi Kawamine, Kimiyuki Shibuya, Fumiyasu Sato, Kimio Sawanobori, Takuya Watanabe, Akira Miyazaki, A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels Atherosclerosis. ,vol. 191, pp. 290- 297 ,(2007) , 10.1016/J.ATHEROSCLEROSIS.2006.05.048
Erik G. Lund, Chonglun Xie, Tiina Kotti, Stephen D. Turley, John M. Dietschy, David W. Russell, Knockout of the Cholesterol 24-Hydroxylase Gene in Mice Reveals a Brain-specific Mechanism of Cholesterol Turnover Journal of Biological Chemistry. ,vol. 278, pp. 22980- 22988 ,(2003) , 10.1074/JBC.M303415200
T. J. Kotti, D. M. O. Ramirez, B. E. Pfeiffer, K. M. Huber, D. W. Russell, Brain cholesterol turnover required for geranylgeraniol production and learning in mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 3869- 3874 ,(2006) , 10.1073/PNAS.0600316103
Torgeir Holen, Mohammed Amarzguioui, Merete T Wiiger, Eshrat Babaie, Hans Prydz, Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor Nucleic Acids Research. ,vol. 30, pp. 1757- 1766 ,(2002) , 10.1093/NAR/30.8.1757