Elevated prostacyclin biosynthesis in mice impacts memory and anxiety-like behavior.
作者： Craig Vollert , Odochi Ohia , Hironari Akasaka , Casey Berridge , Ke-He Ruan
DOI: 10.1016/J.BBR.2013.10.012
关键词:
摘要: Prostacyclin is an endogenous lipid metabolite with properties of vasodilation and anti-platelet aggregation. While the effects prostacyclin on vascular protection have been well-documented, role this eicosanoid in central nervous system has not extensively studied. Recently, a transgenic mouse containing hybrid enzyme, cyclooxygenase-1 linked to synthase, was developed that produces elevated levels vivo. The goal study investigate whether increased biosynthesis could affect behavioral phenotypes mice. Our results uncovered broadly both cognitive non-cognitive behaviors, including decreased anxiety-like behavior improved learning fear-conditioning memory test. This demonstrates plays important, but previously unrecognized, function behavior.
sci-hub.se 参考文章(49)
Jacqueline N. Crawley, Kathleen R. Bailey, Anxiety-Related Behaviors in Mice CRC Press/Taylor & Francis. ,(2009)
Ke-He Ruan, Richard A F Dixon, James T Willerson, Cheng-Huai Ruan, Prostacyclin Therapy for Pulmonary Arterial Hypertension Texas Heart Institute Journal. ,vol. 37, pp. 391- 399 ,(2010)
Ke-He Ruan, Shui-Ping So, Vanessa Cervantes, Hanjing Wu, Cori Wijaya, Rebecca R. Jentzen, An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector. FEBS Journal. ,vol. 275, pp. 5820- 5829 ,(2008) , 10.1111/J.1742-4658.2008.06703.X
Takahiko Murata, Fumitaka Ushikubi, Toshiyuki Matsuoka, Masakazu Hirata, Atsushi Yamasaki, Yukihiko Sugimoto, Atsushi Ichikawa, Yoshiya Aze, Takashi Tanaka, Nobuaki Yoshida, Akinori Ueno, Sachiko Oh-ishi, Shuh Narumiya, Altered pain perception and inflammatory response in mice lacking prostacyclin receptor Nature. ,vol. 388, pp. 678- 682 ,(1997) , 10.1038/41780
Peter Bentzer, Daniele Venturoli, Ola Carlsson, P.-O. Grände, Low-dose prostacyclin improves cortical perfusion following experimental brain injury in the rat. Journal of Neurotrauma. ,vol. 20, pp. 447- 461 ,(2003) , 10.1089/089771503765355522
Anantha Vijay R. Santhanam, Leslie A. Smith, Zvonimir S. Katusic, Brain-Derived Neurotrophic Factor Stimulates Production of Prostacyclin in Cerebral Arteries Stroke. ,vol. 41, pp. 350- 356 ,(2010) , 10.1161/STROKEAHA.109.564492
A A Hagen, R P White, J T Robertson, Synthesis of prostaglandins and thromboxane B2 by cerebral arteries. Stroke. ,vol. 10, pp. 306- 309 ,(1979) , 10.1161/01.STR.10.3.306
H Pickles, M M Brown, M Thomas, A H Hewazy, S Redmond, E Zilkha, J Marshall, Effect of indomethacin on cerebral blood flow, carbon dioxide reactivity and the response to epoprostenol (prostacyclin) infusion in man. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 47, pp. 51- 55 ,(1984) , 10.1136/JNNP.47.1.51
Craig Vollert, Munder Zagaar, Iris Hovatta, Manish Taneja, Anthony Vu, An Dao, Amber Levine, Karim Alkadhi, Samina Salim, Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: Potential role of oxidative stress mechanisms Behavioural Brain Research. ,vol. 224, pp. 233- 240 ,(2011) , 10.1016/J.BBR.2011.05.010
Mary Elhardt, Luis Martinez, Maria Victoria Tejada-Simon, Neurochemical, behavioral and architectural changes after chronic inactivation of NMDA receptors in mice Neuroscience Letters. ,vol. 468, pp. 166- 171 ,(2010) , 10.1016/J.NEULET.2009.10.091