Brain-Derived Neurotrophic Factor Stimulates Production of Prostacyclin in Cerebral Arteries
作者： Anantha Vijay R. Santhanam , Leslie A. Smith , Zvonimir S. Katusic
DOI: 10.1161/STROKEAHA.109.564492
关键词:
摘要: Background and Purpose—The role of brain-derived neurotrophic factor (BDNF) its receptor, tropomyosin receptor kinase B, in control cerebral circulation is poorly understood. The present study was designed to investigate the vascular effects BDNF vivo. Methods—Replication incompetent adenovirus encoding either rat (AdBDNF) or green fluorescent protein injected intracisternally into rabbits. Forty-eight hours later, animals were euthanized. Plasma cerebrospinal fluid levels measured by enzyme-linked immunosorbent assay, vasomotor function isolated basilar arteries studied organ chambers, expression Western blotting, prostanoid cyclic adenosine 3′,5′-monophosphate radioimmunoassay. Results—The significantly elevated AdBDNF-treated rabbits as compared with enc...
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