作者: Donald G. Stein
DOI: 10.1016/J.YHBEH.2012.05.004
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摘要: Abstract This article is part of a Special Issue "Hormones & Neurotrauma". Despite decades laboratory research and clinical trials, safe effective treatment for traumatic brain injury (TBI) has yet to be put into successful use. I suggest that much the problem can attributed reductionist perspective attendant strategy directed finding or designing drugs target single receptor mechanism, gene, locus. approach fails address complexity TBI, which leads cascade systemic toxic events in throughout body may persist over long periods time. Attention now turning pleiotropic drugs: act on multiple genomic, proteomic metabolic pathways enhance morphological functional outcomes after injury. Of various agents neurosteroid progesterone (PROG) gaining attention despite widespread assumption it “just female hormone” with limited, if any, neuroprotective properties. should change. PROG also powerful developmental hormone plays critical role protecting fetus during gestation. argue here development, neuroprotection cellular repair have number properties common. discuss evidence pleiotropically useful therapeutic agent central nervous system some neurodegenerative diseases.