A clinical/translational perspective: can a developmental hormone play a role in the treatment of traumatic brain injury?

作者: Donald G. Stein

DOI: 10.1016/J.YHBEH.2012.05.004

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摘要: Abstract This article is part of a Special Issue "Hormones & Neurotrauma". Despite decades laboratory research and clinical trials, safe effective treatment for traumatic brain injury (TBI) has yet to be put into successful use. I suggest that much the problem can attributed reductionist perspective attendant strategy directed finding or designing drugs target single receptor mechanism, gene, locus. approach fails address complexity TBI, which leads cascade systemic toxic events in throughout body may persist over long periods time. Attention now turning pleiotropic drugs: act on multiple genomic, proteomic metabolic pathways enhance morphological functional outcomes after injury. Of various agents neurosteroid progesterone (PROG) gaining attention despite widespread assumption it “just female hormone” with limited, if any, neuroprotective properties. should change. PROG also powerful developmental hormone plays critical role protecting fetus during gestation. argue here development, neuroprotection cellular repair have number properties common. discuss evidence pleiotropically useful therapeutic agent central nervous system some neurodegenerative diseases.

参考文章(114)
E.E Baulieu, P Robel, M Schumacher, Neurosteroids: Beginning of the story International Review of Neurobiology. ,vol. 46, pp. 1- 32 ,(2001) , 10.1016/S0074-7742(01)46057-0
Iqbal Sayeed, Donald G. Stein, Progesterone as a neuroprotective factor in traumatic and ischemic brain injury. Progress in Brain Research. ,vol. 175, pp. 219- 237 ,(2009) , 10.1016/S0079-6123(09)17515-5
Odette A. Harris, Carrie R. Muh, Monique C. Surles, Yi Pan, Grace Rozycki, Jana Macleod, Kirk Easley, Discrete cerebral hypothermia in the management of traumatic brain injury: a randomized controlled trial. Journal of Neurosurgery. ,vol. 110, pp. 1256- 1264 ,(2009) , 10.3171/2009.1.JNS081320
David W. Wright, Martha E. Bauer, Stuart W. Hoffman, Donald G. Stein, Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats. Journal of Neurotrauma. ,vol. 18, pp. 901- 909 ,(2001) , 10.1089/089771501750451820
Thomas W. McAllister, Anna L. Tyler, Laura A. Flashman, C. Harker Rhodes, Brenna C. McDonald, Andrew J. Saykin, Tor D. Tosteson, Gregory J. Tsongalis, Jason H. Moore, Polymorphisms in the Brain-Derived Neurotrophic Factor Gene Influence Memory and Processing Speed One Month after Brain Injury Journal of Neurotrauma. ,vol. 29, pp. 1111- 1118 ,(2012) , 10.1089/NEU.2011.1930
Jon Nilsen, Alison Morales, Roberta Diaz Brinton, Medroxyprogesterone acetate exacerbates glutamate excitotoxicity Gynecological Endocrinology. ,vol. 22, pp. 355- 361 ,(2006) , 10.1080/09513590600863337
Chun-Hua Hang, Ji-Xin Shi, Bing-Wei Sun, Jie-Shou Li, Apoptosis and functional changes of dipeptide transporter (PepT1) in the rat small intestine after traumatic brain injury. Journal of Surgical Research. ,vol. 137, pp. 53- 60 ,(2007) , 10.1016/J.JSS.2006.06.026
Ronald W. Irwin, Jia Yao, Syeda S. Ahmed, Ryan T. Hamilton, Enrique Cadenas, Roberta Diaz Brinton, Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function. Endocrinology. ,vol. 152, pp. 556- 567 ,(2011) , 10.1210/EN.2010-1061
Robert Vink, Alan J. Nimmo, Multifunctional drugs for head injury Neurotherapeutics. ,vol. 6, pp. 28- 42 ,(2009) , 10.1016/J.NURT.2008.10.036
Antonios Mammis, Tracy K. McIntosh, Allen H. Maniker, Erythropoietin as a neuroprotective agent in traumatic brain injury Surgical Neurology. ,vol. 71, pp. 527- 531 ,(2009) , 10.1016/J.SURNEU.2008.02.040