Progesterone protects normative anxiety-like responding among ovariectomized female mice that conditionally express the HIV-1 regulatory protein, Tat, in the CNS.

摘要: Increased anxiety is co-morbid with human immunodeficiency virus (HIV) infection. Actions of the neurotoxic HIV-1 regulatory protein, Tat, may contribute to affective dysfunction. We hypothesized that Tat expression would increase anxiety-like behavior female GT-tg bigenic mice express protein in brain a doxycycline-dependent manner. Furthermore, given reports HIV-induced occur at lower rates among women, and effects are ameliorated by sex steroids vitro, we 17β-estradiol and/or progesterone ameliorate Tat-induced effects. Among naturally-cycling proestrous diestrous mice, Tat-induction via 7 days doxycycline treatment significantly increased responding an open field, elevated plus maze marble-burying task, compared saline. Proestrous demonstrated less than field maze, but these did not interact Tat-induction. ovariectomized doxycycline-induced marble burying task saline-treated (where was already maximal). Co-administration (4 mg/kg), (0.09 tasks. When administered together, partially antagonized protective on behavior. These findings support evidence steroid-protection over proteins, extend them demonstrating capacity mice.