Impact of Rituximab and Radiotherapy on Outcome of Patients With Aggressive B-Cell Lymphoma and Skeletal Involvement
作者： Gerhard Held , Samira Zeynalova , Niels Murawski , Marita Ziepert , Barbara Kempf
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摘要: Purpose To study clinical presentation, outcome, and the role of radiotherapy in patients with aggressive B-cell lymphoma skeletal involvement treated without rituximab. Patients Methods Outcome was analyzed a retrospective nine consecutive prospective trials German High-Grade Non-Hodgkin Study Group. Results Of 3,840 patients, 292 (7.6%) had involvement. In MabThera International Trial (MInT) for young good-prognosis Rituximab With CHOP Over 60 Years (RICOVER-60) elderly randomized addition rituximab improved event-free survival (EFS; hazard ratio MInT [HRMInT] = 0.4, P > 001; RICOVER-60 [HRRICOVER-60] 0.6, .001) overall (OS; HRMInT < .001; HRRICOVER-60 0.7, .002) involvement, but failed to improve outcome (EFS: 1.4, .444; HRRICOV...
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