A Case-Control Study of Oral Contraceptive Use and Invasive Epithelial Ovarian Cancer

摘要: The relation of oral contraceptive use to the risk ovarian cancer was assessed with data collected during 1977-1991 from patients under 65 years age in hospitals Boston, New York, Philadelphia, and Baltimore. We compared 441 women recently diagnosed invasive epithelial 2,065 control women. Logistic regression used factors for cancer. multivariate relative estimate decreased increasing duration (p or = 3 use, 0.6 (95% confidence interval 0.4-0.8). inverse association > consistently present across categories age, parity, interview year, geographic area. It apparent as long 15-19 after cessation. Many different specific formulations appeared related a risk; however, were sparse newer types, particularly phasic preparations, ability assess preparations context multiple limited. confirm previous reports an several duration. They also suggest that may persist two decades it is not confined any particular type formulation.