Multifunctional decoration of alpha-tocopheryl succinate-based NP for cancer treatment: effect of TPP and LTVSPWY peptide.

摘要: Active targeting not only of a specific cell but also organelle maximizes the therapeutic activity minimizing adverse side effects in healthy tissues. The present work describes synthesis, characterization, and vitro biological active nanoparticles (NP) for cancer therapy based on α-tocopheryl succinate (α-TOS), well-known mitocan, that selectively induces apoptosis cells proliferalting endothelial cells. Human epidermal growth factor receptor 2 (HER2) peptide LTVSPWY (PEP) triphenylphosphonium lipophilic cation (TPP) were conjugated to previously optimized RAFT block copolymer formed self-assembled NP appropriate size this application low polydispersity by self-organized precipitation method. PEP TPP included order target HER2 positive cells, mitochondria these respectively. experiments demonstrated faster incorporation active-targeting higher accumulation TPP-bearing MDA-MB-453 compared non-decorated NP. Moreover, encapsulation additional α-TOS hydrophobic core was achieved with high efficiencies. loaded presented cytotoxicity than unloaded preserved their selectivity against range tested concentrations.