Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies.

摘要: Pancreatic cancer is the eighth major form of cancer-related death worldwide, causing 227 000 deaths annually. Type-II diabetes widely considered to be associated with pancreatic cancer, but whether this represents a causal or consequential association unclear. We conducted meta-analysis examine association. A computer-based literature search from 1966 2005 yielded 17 case–control and 19 cohort nested studies information on 9220 individuals cancer. The age sex-adjusted odds ratio (OR) for type-II was obtained each study. combined summary 1.82 (95% confidence interval CI) 1.66–1.89), evidence heterogeneity across (P=0.002 P=0.05 studies) that explained, in part, by higher risks being reported smaller before 2000. Individuals whom had only recently been diagnosed (<4 years) 50% greater risk malignancy compared who ⩾5 years (OR 2.1 vs 1.5; P=0.005). These results support modest between