Remodeling the cancer epigenome: mutations in the SWI/SNF complex offer new therapeutic opportunities.
作者： Krystal A Orlando , Vinh Nguyen , Jesse R Raab , Tara Walhart , Bernard E Weissman
DOI: 10.1080/14737140.2019.1605905
关键词:
摘要: INTRODUCTION Cancer genome sequencing studies have discovered mutations in members of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex nearly 25% human cancers. The SWI/SNF complex, first S. cerevisiae, shows strong conservation from yeast to Drosophila mammals, contains approximately 10-12 subunits and regulates nucleosome positioning through energy generated by its ATPase subunits. unexpected finding frequent has fueled identify mechanisms that drive tumor development accompanying therapeutic vulnerabilities. Areas covered: In review, we focus upon potential roles different subunit play oncogenesis, their common unique transformation for translating these into targeted therapies SWI/SNF-mutant tumors. Expert opinion: We currently limited insights how Because participates a broad range normal cellular functions, defining specific oncogenic pathways proved difficult. addition, options cancers mainly evolved high-throughput screens cell lines with Future should follow more coherent plan pinpoint vulnerabilities among
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