Mechanical cues in orofacial tissue engineering and regenerative medicine.
作者： Katrien M. Brouwer , Ditte M. S. Lundvig , Esther Middelkoop , Frank A. D. T. G. Wagener , Johannes W. Von den Hoff
DOI: 10.1111/WRR.12283
关键词:
摘要: Cleft lip and palate patients suffer from functional, aesthetical, psychosocial problems due to suboptimal regeneration of skin, mucosa, skeletal muscle after restorative cleft surgery. The field tissue engineering regenerative medicine (TE/RM) aims restore the normal physiology tissues organs in conditions such as birth defects or injury. A crucial factor cell differentiation, formation, function is mechanical strain. Regardless this, cues are not yet widely used TE/RM. effects stimulation on cells straight-forward vitro cellular responses may differ with type loading regime, complicating translation a therapeutic protocol. We here give an overview different types strain that act discuss muscle, skin mucosa. conclude presently, sufficient knowledge lacking reproducibly implement external TE/RM approaches. Mechanical can be applied by fine-tuning stiffness architecture constructs guide differentiation seeded invading surrounding cells. This already improve treatment orofacial clefts other disorders affecting soft tissues.
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Yang Ju, Baiyao Xu, Yasuyuki Morita, Sachi Watanabe, Determination of optimal cyclic uniaxial stretches for stem cell-to-tenocyte differentiation under a wide range of mechanical stretch conditions by evaluating gene expression and protein synthesis levels. Acta of Bioengineering and Biomechanics. ,vol. 15, pp. 71- 79 ,(2013)
Rei Ogawa, Kazuhisa Okai, Fumio Tokumura, Kazuyuki Mori, Yasutaka Ohmori, Chenyu Huang, Hiko Hyakusoku, Satoshi Akaishi, None, The relationship between skin stretching/contraction and pathologic scarring: the important role of mechanical forces in keloid generation. Wound Repair and Regeneration. ,vol. 20, pp. 149- 157 ,(2012) , 10.1111/J.1524-475X.2012.00766.X
Geoffrey Goldspink, Gene expression in muscle in response to exercise Journal of Muscle Research and Cell Motility. ,vol. 24, pp. 121- 126 ,(2003) , 10.1023/A:1026041228041
Robin M Delaine-Smith, Gwendolen C Reilly, Mesenchymal stem cell responses to mechanical stimuli Muscles, ligaments and tendons journal. ,vol. 2, pp. 169- 180 ,(2012)
Patrick Daigle, Marc-Antoine Despatis, Guillaume Grenier, How mechanical deformations contribute to the effectiveness of negative‐pressure wound therapy Wound Repair and Regeneration. ,vol. 21, pp. 498- 502 ,(2013) , 10.1111/WRR.12052
C Cacou, D L Bader, J C Shelton, D A Lee, C C Berry, Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner. Biorheology. ,vol. 40, pp. 337- 345 ,(2003)
Pauline D. Verhaegen, Hennie J. Schouten, Wikky Tigchelaar-Gutter, Jan van Marle, Cornelis J. van Noorden, Esther Middelkoop, Paul P. van Zuijlen, Adaptation of the dermal collagen structure of human skin and scar tissue in response to stretch: an experimental study. Wound Repair and Regeneration. ,vol. 20, pp. 658- 666 ,(2012) , 10.1111/J.1524-475X.2012.00827.X
Henry J. C de Vries, Dory N. H Enomoto, Jan van Marle, Paul P. M van Zuijlen, Jan R Mekkes, Jan D Bos, Dermal organization in scleroderma: the fast Fourier transform and the laser scatter method objectify fibrosis in nonlesional as well as lesional skin. Laboratory Investigation. ,vol. 80, pp. 1281- 1289 ,(2000) , 10.1038/LABINVEST.3780136
Jenna Leigh Balestrini, Kristen Lawrence Billiar, Equibiaxial cyclic stretch stimulates fibroblasts to rapidly remodel fibrin. Journal of Biomechanics. ,vol. 39, pp. 2983- 2990 ,(2006) , 10.1016/J.JBIOMECH.2005.10.025
T.E. Danciu, E. Gagari, R.M. Adam, P.D. Damoulis, M.R. Freeman, Mechanical Strain Delivers Anti-apoptotic and Proliferative Signals to Gingival Fibroblasts Journal of Dental Research. ,vol. 83, pp. 596- 601 ,(2004) , 10.1177/154405910408300803