Brain Plasticity and Stroke Rehabilitation

摘要: Neuronal connections and cortical maps are continuously remodeled by our experience. Knowledge of the potential capabilityof brain to compensate for lesions is a prerequisite optimal stroke rehabilitation strategies. Experimental focal induce changes in adjacent cortex contralateral hemisphere. Neuroimaging studies patients indicate altered poststroke activation patterns, which suggest some functional reorganization. To what extent imaging data correspond outcome needs be evaluated. Reorganization may principle process responsible recovery function after stroke, but limits, can postischemic intervention facilitate such changes? Postoperative housing animals an enriched environment significantly enhance also interact with other interventions, including neocortical grafting. What role will neuronal progenitor cells play future rehabilitation-stimulated situ or as neural replacement? And blocking growth inhibitory factors? Better knowledge molecular neurophysiological events, close interaction between basic applied research, hopefully enable us design strategies based on neurobiological principles not-too-distant future.