Growth hormone-binding proteins in plasma.

摘要: Two growth hormone-binding proteins (GHBPs), one with high and the other low affinity, have recently been described in blood of humans several species. The high-affinity GHBP represents a circulating fragment GH receptor, encompassing its extracellular domain. molecular nature low-affinity is not known detail. GHBPs form complexes GH, prolong biological half-life, restrict distribution body, modulate binding to receptors tissues. Their net effect vivo enhance action. level plasma probably reflects receptor concentrations level/activity linked action, congenital or acquired conditions altered levels are characterized by parallel changes action (Laron-type dwarfism, pygmy malnutrition, obesity, insulin-dependent diabetes mellitus, liver cirrhosis, renal insufficiency). GHBP/receptor nutritionally regulated, undernutrition overnutrition. Regulation lean body mass anabolism/catabolism at provides rational explanation for derangements axis their consequences (retarded accelerated somatic growth) observed nutrition disorders.