Radiation-induced tumor neoantigens: imaging and therapeutic implications.

摘要: Exposure of tumor cells to ionizing radiation (IR) is widely known induce a number cellular changes. One way that IR can affect through the development neoantigens which are new molecules express at cell membrane following some insult or change cell. There have been numerous reports in literature changes both and vasculature surface molecule expression treatment with IR. The usefulness for imaging therapeutic applications lies fact they differentially expressed on irradiated greater extent than normal tissues. This differential provides mechanism by be "marked" further targeting. Drug delivery vehicles agents conjugated ligands recognize interact help improve tumor-specific targeting reduce systemic toxicity cancer drugs. article review reported response either vivo vitro. Additionally, we provide discussion methods used identification these antigens their use drug imaging.