In vitro cardiovascular system emulator (bioreactor) for the simulation of normal and diseased conditions with and without mechanical circulatory support

摘要: This article presents a new device designed to simulate in vitro flow rates, pressures, and other parameters representing normal diseased conditions of the human cardiovascular system. Such devices are sometimes called bioreactors or "mock" simulator loops (SCVLs) literature. Most SCVLs systemic circulation only have inherent limitations studying interaction left right sides circulation. Those that include both utilize header reservoirs simulating cycles with constant atrial pressures. The SCVL described this includes models for all four chambers heart, pulmonary loops. Each heart chamber is accurately activated by separate linear motor suction ejection stages, thus capturing important features perfusion waveforms. Four mechanical valves corresponding mitral, pulmonary, tricuspid, aortic used control desired unidirectional flow. can emulate different physiological pathological system controlling blood through vascular tree (mainly resistance, compliance, elastance chambers). In study, cases were simulated: healthy, congestive failure, ventricular diastolic dysfunction conditions, addition circulatory support (MCS) device. Hemodynamic including pressure, been investigated at sinus, carotid artery, respectively. an MCS resulted significant reduction mean pressure re-establishment cardiac output. cases, experimental results compared physiology numerical simulations. show capability replicate various without MCS.