Carboxylated Agarose (CA)-Silk Fibroin (SF) Dual Confluent Matrices Containing Oriented Hydroxyapatite (HA) Crystals: Biomimetic Organic/Inorganic Composites for Tibia Repair
作者： Jing-Xiao Hu , Jia-Bing Ran , Si Chen , Pei Jiang , Xin-Yu Shen
DOI: 10.1021/ACS.BIOMAC.6B00587
关键词:
摘要: By in situ combining the dual cross-linking matrices of carboxylated agarose (CA) and silk fibroin (SF) with hydroxyapatite (HA) crystals, CA-SF/HA composites optimal physicochemical biological properties were obtained, which designed to meet clinical needs load-bearing bone repair. With synergistic modulation organic matrices, HA nanoparticles presented sheet rod morphologies due preferred orientation, successfully simulated biomineralization nature. The chemical reactivity native (NA) was significantly enhanced via carboxylation, CA exhibited higher thermal stability than NA. In presence SF, showed mechanical that could standard degradation SF delayed such rate implant satisfy growth newly formed tissue. vi...
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