Subcutaneously Injected Radiolabeled Liposomes: Transport to the Lymph Nodes in Mice

摘要: Male A/He mice were given sc injections in the feet with [3,5,3'-125I]triiodothyronine, [125I]T3, either free state or encapsulated within sonicated phosphatidylcholine liposomes. Radioactivity was recovered from injection site, popliteal lymph nodes (LN), blood, liver, lungs, and spleen at various times (5 min to 6 hr) after injection. The highest level of radioactivity found LN liposome-encapsulated (LE) [125I]T3: For more than 3 hours injection, fivefold fiftyfold higher there that all other organs including [125I]T3. results demonstrated injected liposomes enter lymphatic pathways reach draining LN. Thus local administration LE antitumor drugs into sites a malignant tumor before its excision might be useful preventing postoperative metastases