Evaluation of retinal haemodynamics and retinal function after application of dorzolamide, timolol and latanoprost in newly diagnosed open-angle glaucoma patients.

摘要: . Purpose: The purpose of this prospective, randomized, cross-over study was to investigate and compare the microcirculatory effects timolol, dorzolamide latanoprost in newly diagnosed primary open-angle glaucoma (POAG) patients. Haemodynamics were assessed using fluorescein angiography by means a scanning laser ophthalmoscope (SLO). Visual function visual field indices evaluated during all drug treatment phases. Methods: Fourteen patients with POAG (age 55 ± 7 years; 10 male, four female) recruited for study. At baseline examination, blood pressure, heart rate, intraocular pressure (IOP), SLO angiograms, contrast sensitivity (CS) analysed. Patients then randomly received or 4 weeks. returned procedures repeated assessed. Arteriovenous passage times (AVPs), peripapillary arterial venous diameters from digital image processing. Calculated ocular perfusion determined each phase. Results: Intraocular significantly lowered compared (p < 0.0001). shortened after application = 0.009), whereas neither timolol nor resulted significant AVP changes. Peripapillary diameters, systolic diastolic rate pressures not altered any phase. Contrast testing at 6 cycles/degree (c.p.d.) revealed rise = 0.007). Conclusion: Our results suggest that patients, had no effect. Given prolonged have been associated disease progression glaucoma; may benefit optic nervehead preservation increasing perfusion.