The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions

摘要: The normal intestinal microbiota inhabits the colon mucus without triggering an inflammatory response. reason for this and how of is organized have begun to be unraveled. in two layers: inner, stratified layer that firmly adherent epithelial cells approximately 50 μm thick; outer, nonattached usually 100 thick as measured mouse. These layers are around highly glycosylated MUC2 mucin, forming a large, net-like polymer secreted by goblet cells. inner dense does not allow bacteria penetrate, thus keeping cell surface free from bacteria. converted into outer layer, which habitat commensal flora. has expanded volume due proteolytic activities provided host but probably also caused bacterial proteases glycosidases. numerous O-glycans on mucin only serve nutrients attachment sites and, such, contribute selection species-specific This observation human individuals carry uniform glycan array may indicate such specific selection.