Transdermal scopolamine alters phasic REM activity in normal young adults.

摘要: Transdermal scopolamine has been widely used for the prevention of motion-sickness by travelers due to its potent anticholinergic effects and ease administration. Nevertheless, on sleep physiology are not known, despite wellknown fact that administration as an injection or oral form could influence architecture, especially prolonging rapid eye movement (REM) latency shortening duration REM sleep. This study aimed measure transdermal in order examine whether it affects previous studies. We studied eight young healthy male adults polysomnographically three nights including one adaptation night a double blind crossover design compared sleep-related variables between sleeps with without patch 1.5 mg. found no differences tonic measures such latency, but phasic total activity (p < 0.05) density were significantly suppressed scopolamine; densities first second periods well fourth period decreased placebo nights. These results suggest components reflect cholinergic mechanism central nervous system (CNS) even at lowest commercial dose, be useful markers CNS activities future research.