Cyanuric chloride catalyzed metal-free mild protocol for the synthesis of highly functionalized tetrahydropyridines

作者: Rathinam Ramesh , Subramani Maheswari , Mani Arivazhagan , Jan Grzegorz Malecki , Appaswami Lalitha

DOI: 10.1016/J.TETLET.2017.08.074

关键词:

摘要: Abstract An environmentally benign, facile and elegant synthetic approach for the convenient access of a series diverse 2,6-diaryl-tetrahydropyridine-3-carboxylates via one-pot, pseudo five-component condensation ethyl acetoacetate, anilines aromatic aldehydes under mild reaction conditions has been described. This domino strategy allows rapid cyclization in presence 10 mol% cyanuric chloride as source hydrochloric acid to afford desired target skeletons excellent yields. The present protocol offers prominent advantages simple operational procedure, metal-free organocatalyst, practically robust extensive substrate scope.

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