Mouse Lbx1 and human LBX1 define a novel mammalian homeo☐ gene family related to the Drosophila lady bird genes

摘要: Abstract We have cloned two novel homeo☐ genes which are the mouse ( Lbx1 ) and human LBX1 homologs of Drosophila lady bird genes. They highly related not only within coding region but also in 5′ 3′ untranslated regions. Several amino acid residues inside around homeodomain, been conserved between mammalian Lbx their counterparts. The gene is located on chromosome 19 (region D) maps to q24 10, known as a breakpoint translocations t(7;10) t(10;14) involved T-cell leukemias. Thus, protooncogene HOX11 map common chromosomal region, do counterparts, 93Bal specifically expressed during embryogenesis. From 10.5 days gestation, expression detected central nervous system some developing muscles. In CNS, transcripts dorsal part mantle layer spinal cord hindbrain, up sharp boundary metencephalon. may be hindbrain differentiation and/or patterning, its restricted pattern could depend upon evolutionarily inductive signals involving Wnt Pax genes, case for wingless or gooseberry .