Drosophila Homeobox Genes

摘要: Publisher Summary This chapter describes what is known about the published members of Drosophila homeobox family and properties some new members. William Bateson originally coined term homeosis to describe pattern defects in segmented animals which a structure from one segment was replaced by different structure, normally found another. Bateson's later used homeotic mutations that were isolated early screens for heritable morphological . Homeobox sequences recognized three segmentation genes: (1) Antennapedia (Antp), ultrabithorax (Ubx), fushi taruzu (Ftz). The highly conserved 60-amino acid regions encode are called “homeodomains”. After discovery motif, it quickly became apparent many other genes family, significant fraction having very similar Antp Ubx, also had functions developmental patterning embryos. gene contains 55 members, distributed throughout genome, most mapping on second third chromosomes. Many map clusters containing two nine