tyk2, prototype of a novel class of non-receptor tyrosine kinase genes.

摘要: We previously identified a novel protein tyrosine kinase gene, tyk2, by screening human lymphoid cDNA library with domain specific c-fms restriction fragment under low stringency hybridization conditions. have now isolated and sequenced full length tyk2 clone; demonstrated that this gene is widely expressed in hematopoietic non-hematopoietic cell lines; mapped it to chromosome 19p13.2. The clone 4176 nucleotides long codes for putative molecular weight of 134 kilodaltons. Hydrophobicity analysis our sequence does not identify transmembrane domain, which found all members the receptor class kinases; nor can we detect an SH2 non-receptor kinases. therefore propose prototype new