Cellular senescence in aging and osteoarthritis.
作者： Wei Seong Toh , Mats Brittberg , Jack Farr , Casper Bindzus Foldager , Andreas H Gomoll
DOI: 10.1080/17453674.2016.1235087
关键词:
摘要: - It is well accepted that age an important contributing factor to poor cartilage repair following injury, and the development of osteoarthritis. Cellular senescence, loss ability cells divide, has been noted as major age-related changes in homeostasis, function, response injury. The underlying mechanisms cellular while not fully understood, have associated with telomere erosion, DNA damage, oxidative stress, inflammation. In this review, we discuss causes consequences biological challenges repair. addition, present novel strategies for modulation senescence may help improve regeneration aging population.
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