PAMAM Dendrimer Based Macromolecules as Improved Contrast Agents
作者： Vincent J. Venditto , Celeste Aida S. Regino , Martin W. Brechbiel
DOI: 10.1021/MP050019E
关键词:
摘要: Dendrimers are an attractive platform for macromolecular imaging due to the presence of multiple terminal groups on exterior molecule. Through application appropriate metal ion chelates, large numbers ions (paramagnetic or radioopaque) and therapy (radioactive particle emitters) may be conjugated dendrimer in combination with a targeting vector, through classic organic synthetic techniques. Thus, amount these potentially site specifically delivered directly into body as vehicle vector directing modified dendrimer. The development targeted agents acceptable blood retention times selective organ uptake then has potential various biological applications. A review comparative studies dendrimers externally appended is presented herein. Keywords: PAMAM dendrimers; contrast agents; imagin...
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