Métodos Alternativos en Toxicología

摘要: The term alternative to animal experimentation describes any change in official protocol that contributes the refinement of techniques, reduction number animals used or replacement them. These principles are known as 3Rs and were defined by Russell Burch their book, Principles Humane Experimental Techniques. modern times has added arguments (economic, sociopolitical legal) togethers with evolution scientific knowledge, support application development methods. However, only a small part these methods is accepted regulatory agencies, just be evaluation risk. Therefore it necessary been scientifically validated. It should prove safe reliable traditional method order replaced. also comply several validation criteria permit define advantages disadvantages test. This review provides brief overview topic alternatives focuses on methods, description. listed most important internationally shown.