Proto-oncogenes: basic concepts and stimulation induced changes in the spinal cord.

摘要: Publisher Summary This chapter discusses Proto-oncogenes. Immediate early genes (IEGs) were originally described as a class of rapidly and transiently expressed in cells stimulated with growth factors, without the requirement for de novo protein synthesis. Evidence is accumulating to suggest that changes IEGs expression within nervous system signal long-term adaptation particular neural pathways. Rapid transient obviously ideal characteristics putative cellular activity markers, pattern could, because rapidity expression, be assumed generated directly by stimulus not mediated polysynaptically or some other process residual trace previous stimulation. However, while value markers vitro cannot disputed, their appearance vivo under far greater control appears tied physiological context stimulus. It argued localization IEG mRNA neurons glial grown may accurately reflect cell has been recently way, product does simply evoked activity, but crucially related type stimulation state animal. regarded , perhaps indicating occurrence significant environmental requires change certain aspects neuronal physiology.