Elevating circulation chemerin level is associated with endothelial dysfunction and early atherosclerotic changes in essential hypertensive patients.

摘要: OBJECTIVES Chemerin is a new adipokine elevated in states of obesity and metabolic syndromes. In this study, we investigated the association increased chemerin on endothelial function, arterial stiffness early atherosclerosis essential hypertensive patients. METHODS Three hundred sixty-seven newly diagnosed patients were enrolled. Anthropometric measurements plasma parameters examined, including BMI, waist circumference, glucose, serum insulin, lipid profiles, chemerin, high-sensitivity C-reactive protein, tumor necrosis factor-α, interleukin-4. Vascular health was assessed with brachial flow-mediated dilatation (FMD), brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (IMT). RESULTS patients, levels higher women than men (P < 0.05). univariate analysis, level positively correlated baPWV (men: r = 0.58, P < 0.01; women: r = 0.51, P < 0.01) IMT r = 0.17, P = 0.01; r = 0.20, P = 0.01), inversely FMD r = -0.54, r = -0.44, P < 0.01). The associations for baPWV, but not IMT, remained significant multivariable models adjusted age, sex, glucose homeostasis, inflammation markers adipokines. More importantly, logistic regression analysis revealed that high an independent predictor impaired function (FMD odds ratio 1.58, 95% confidence interval 1.28-3.30, P = 0.03) (baPWV 3.75, 1.36-5.28, P < 0.01), even after adjustment variables, inflammatory CONCLUSION independently associated index hypertension.