Magnetofluorescent photothermal micelles packaged with GdN@CQDs as photothermal and chemical dual-modal therapeutic agents
作者： Ming Zhang , Jing Wang , Wentao Wang , Jun Zhang , Ninglin Zhou
DOI: 10.1016/J.CEJ.2017.07.138
关键词:
摘要: Abstract Carbon dots could be extended in biological applications for drug delivery and photothermal therapeutics due to their ability improving therapeutic effect reducing side effects. Here, we use doxorubicin (DOX) as the model drug, amino carboxyl coated magnetofluorescent carbon quantum (GdN@CQDs) a carrier, Genipin (GP) cross-linking agent design prepare multifunctional system triggered by near-infrared (NIR) light pH dual-stimuli. The cytotoxicity of nanoparticles has been examined MTT assay. fluorescent GdN@CQDs/GP serves both controllable release gatekeeper probe visualization process. In vitro vivo experiments showed that this platform can deliver anti-cancer drugs cells, releasing them intracellular upon NIR irradiation, effectively eliminate tumors through chemo-photothermal synergistic effect.
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