Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

摘要: Nanoparticle-based drug delivery systems have been developed to improve the efficacy and reduce systemic toxicity of a wide range drugs. Although clinically approved nanoparticles consistently shown value in reducing toxicity, their use has not always translated into improved clinical outcomes. This led development "multifunctional" nanoparticles, where additional capabilities like targeting image contrast enhancement are added nanoparticles. However, functionality means synthetic steps costs, more convoluted behavior effects vivo, also greater regulatory hurdles. The trade-off between complexity is subject ongoing debate focus this Review.