The Floccular Syndrome: Dynamic Changes in Eye Movements and Vestibulo-ocular Reflex in Isolated Infarction of the Cerebellar Flocculus

摘要: The cerebellar flocculus is a critical structure involved in the control of eye movements. Both static and dynamic abnormalities vestibulo-ocular reflex (VOR) have been described animals with experimental lesions flocculus/paraflocculus complex. In humans, restricted to are rare so they can become an exceptional model contrast clinical features or patients more generalized diseases. Here, we examined 67-year-old patient acute vestibular syndrome due isolated infarct right flocculus. We evaluated him multiple times over 6 months—to follow changes movements function—with caloric testing, video-oculography head-impulse anatomical on imaging. Acutely, he had ipsilateral-beating spontaneous nystagmus, bilateral gaze-evoked borderline impaired smooth pursuit, complete contraversive ocular tilt reaction. VOR gain was reduced for head impulses directed contralateral lesion, there also ipsilesional weakness. All progressively improved at follow-up visits but considerable reduction volume affected motor findings, qualitatively similar previously reported patient, further clarify “acute floccular syndrome” humans. add new information about pattern recovery from such lesion corresponding size