Negative regulation of c-abl tyrosine kinase by its variable N-terminal amino acids.

摘要: Activation of the oncogenic potential c-abl proto-oncogene has been correlated with activation its tyrosine kinase activity. The oncogenes derived from c-abl, e.g., gag/v-abl in Abelson murine leukemia virus or bcr/abl chronic myelogenous leukemia, lack N-terminal coding sequences normal gene. In mouse and human cells, two sets amino acids encoded by 5'-variable exons are found proteins. To assess importance deletion kinase, a full length an deleted protein was expressed bacteria monkey COS cells. Measurements autokinase activity these proteins showed that led to three five fold increase Thus, is important proto-oncogene.