A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.

摘要: Abstract The ubiquitously expressed c-Abl tyrosine kinase is localized to the nucleus and binds DNA. DNA binding activity regulated by cdc2-mediated phosphorylation, suggesting a cell cycle function for c-Abl. Here we show that of nuclear in through specific interaction with retinoblastoma protein (RB). A domain C-terminus RB, outside AB pocket, ATP-binding lobe kinase, resulting inhibition. RB-c-Abl not affected viral oncoproteins bind RB. Hyperphosphorylation RB correlates release activation S phase cells. can enhance transcription, this inhibited Nuclear an phase-activated may participate directly regulation transcription.