Long non-coding RNA NEAT1 regulates epithelial membrane protein 2 expression to repress nasopharyngeal carcinoma migration and irradiation-resistance through miR-101-3p as a competing endogenous RNA mechanism
作者： Yujia Wang , Chunting Wang , Can Chen , Fengbo Wu , Pengfei Shen
DOI: 10.18632/ONCOTARGET.19596
关键词:
摘要: The altered expression of long non-coding RNAs (lncRNAs) is often related to carcinogenesis, metastasis and resistance radiation or chemotherapy. In the current study, cDNA microarray analysis found that NEAT1 was reduced in nasopharyngeal carcinoma (NPC) patients it regulated NPC progression. However, detailed mechanisms were unclear. repressed cell growth, invasion vitro tumor vivo. addition, results an approach integrating bioinformatics, luciferase reporter assays RNA immunoprecipitation indicated antagonized miR-101-3p through a competing endogenous (ceRNA) mechanism interaction between EMP2 dependent. Our showed novel connection NEAT1, migration resistance.
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