RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion.
作者： Rajeev K. Boregowda , Oyenike O. Olabisi , Walid Abushahba , Byeong-Seon Jeong , Keneshia K. Haenssen
DOI: 10.1016/J.CANLET.2014.03.011
关键词:
摘要: In the present study, we investigated role of transcription factor RUNX2 in melanomagenesis. We demonstrated that expression transcriptionally active was increased melanoma cell lines as compared with human melanocytes. Using a tissue microarray, showed levels were higher cells nevic knockdown significantly decreased Focal Adhesion Kinase expression, and inhibited their growth, migration invasion ability. Finally, pro-hormone cholecalciferol reduced transcriptional activity cells, further suggesting migration.
eewoww.com
researchgate.net 参考文章(56)
Takashi Fujita, Yasutaka Azuma, Ryo Fukuyama, Yuji Hattori, Carolina Yoshida, Masao Koida, Kiyokazu Ogita, Toshihisa Komori, Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling Journal of Cell Biology. ,vol. 166, pp. 85- 95 ,(2004) , 10.1083/JCB.200401138
Levi A. Garraway, Hans R. Widlund, Mark A. Rubin, Gad Getz, Aaron J. Berger, Sridhar Ramaswamy, Rameen Beroukhim, Danny A. Milner, Scott R. Granter, Jinyan Du, Charles Lee, Stephan N. Wagner, Cheng Li, Todd R. Golub, David L. Rimm, Matthew L. Meyerson, David E. Fisher, William R. Sellers, Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma Nature. ,vol. 436, pp. 117- 122 ,(2005) , 10.1038/NATURE03664
Nathalie Dhomen, Jorge S. Reis-Filho, Silvy da Rocha Dias, Robert Hayward, Kay Savage, Veronique Delmas, Lionel Larue, Catrin Pritchard, Richard Marais, Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell. ,vol. 15, pp. 294- 303 ,(2009) , 10.1016/J.CCR.2009.02.022
J Akech, J J Wixted, K Bedard, M van der Deen, S Hussain, T A Guise, A J van Wijnen, J L Stein, L R Languino, D C Altieri, J Pratap, E Keller, G S Stein, J B Lian, Runx2 association with progression of prostate cancer in patients: Mechanisms mediating bone osteolysis and osteoblastic metastatic lesions Oncogene. ,vol. 29, pp. 811- 821 ,(2010) , 10.1038/ONC.2009.389
Florian Otto, Anders P Thornell, Tessa Crompton, Angela Denzel, Kimberly C Gilmour, Ian R Rosewell, Gordon W.H Stamp, Rosa S.P Beddington, Stefan Mundlos, Bjorn R Olsen, Paul B Selby, Michael J Owen, Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development Cell. ,vol. 89, pp. 765- 771 ,(1997) , 10.1016/S0092-8674(00)80259-7
David Ghosh, Athanasios Papavassiliou, Transcription factor therapeutics: long-shot or lodestone. Current Medicinal Chemistry. ,vol. 12, pp. 691- 701 ,(2005) , 10.2174/0929867053202197
Chee-Wai Chua, Yung-Tuen Chiu, Hiu-Fung Yuen, Kwok-Wah Chan, Kwan Man, Xianghong Wang, Ming-Tat Ling, Yong-Chuan Wong, Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform. Clinical Cancer Research. ,vol. 15, pp. 4322- 4335 ,(2009) , 10.1158/1078-0432.CCR-08-3157
Margaretha van der Deen, Jacqueline Akech, David Lapointe, Sneha Gupta, Daniel W. Young, Martin A. Montecino, Mario Galindo, Jane B. Lian, Janet L. Stein, Gary S. Stein, Andre J. van Wijnen, Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility Journal of Biological Chemistry. ,vol. 287, pp. 4503- 4517 ,(2012) , 10.1074/JBC.M111.287771
Satyajit K. Mitra, Daniel A. Hanson, David D. Schlaepfer, Focal adhesion kinase: in command and control of cell motility Nature Reviews Molecular Cell Biology. ,vol. 6, pp. 56- 68 ,(2005) , 10.1038/NRM1549
Danny R. Welch, J. E. Bisi, B. E. Miller, D. Conaway, E. A. Seftor, K. H. Yohem, L. B. Gilmore, R. E. B. Seftor, M. Nakajima, Mary J. C. Hendrix, Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line. International Journal of Cancer. ,vol. 47, pp. 227- 237 ,(1991) , 10.1002/IJC.2910470211