Physiological and pathological regulation of the autonomic control of urinary bladder contractility

摘要: The urinary bladder stores urine for most of the day, a process facilitated by beta-adrenergic receptor-mediated detrusor relaxation and alpha(1)-adrenergic contraction neck. Physiological voiding is caused induced muscarinic receptor stimulation. This manuscript reviews data on alterations alpha(1)- responsiveness related to gender, developmental maturation, ageing pathophysiological conditions such as diabetes, arterial hypertension outlet obstruction, all which can be associated with function overactivity. existing show that none overactivity exhibit increased could explain clinical observations; while not being fully consistent, they if anything reduced responsiveness. On other hand, more limited demonstrate may enhanced in states However, are too sparse and/or inconsistent allow definitive conclusions. Thus, distinct from those autonomic receptors better candidates dysfunction.