Gender specificity of tolterodine on micturition and the diurnal variation of urine production of the conscious rat.

摘要: Objective To evaluate the effect of oral administration tolterodine on diurnal micturition characteristics male and female conscious rat, to examine relative in influencing water consumption urine production. Materials methods Baseline volume frequency nine 10 Sprague-Dawley age-matched adult rats (body weight 399 ± 15 249 ± 3 g, respectively) were evaluated over 24-h. Initial hydration conditions standardized with an dose (5 mL) water. Rats subsequently placed a metabolic cage had free access Micturition volume/frequency derived from measurements voided (measured using digital balance below connected computer). The total consumed 24 h was also measured. Two separate baseline studies conducted, followed by single 1 mg/mL dissolved 5 mL mean per computed 3-h periods plotted 24-h period. In addition, values number micturitions volumes during day/dark cycle evaluated. Results data showed that females (when corrected for body weight) consistently imbibed significantly more (83%) than did rats. Tolterodine not affect males but reduced 42%. amount produced production 26%. increased voids compared day night. More importantly produce no significant either or night cycle, decreased females. Conclusions These results suggest is gender-specific, suppressing rats, decreasing bladder volume. There possibility reported clinical effects arise through suppression fluid consumption.