Antibodies to infectious agents in individuals at ultra-high risk for psychosis.

作者: G. Paul Amminger , Patrick D. McGorry , Gregor E. Berger , Darryl Wade , Alison R. Yung

DOI: 10.1016/J.BIOPSYCH.2006.09.034

关键词:

摘要: Background While there is evidence that some cases of schizophrenia may be associated with microbial infections, the role agents has not been investigated in people emerging psychosis. Methods Participants were 105 help seeking ultra-high risk individuals. Psychiatric measures included Brief Rating Scale and for Assessment Negative Symptoms. Serum IgG antibodies against human herpesviruses Toxoplasma gondii determined using immunoassay methods. Multiple linear regression adjustment age sex was applied to test associations between serum psychiatric measures. Results Higher levels Toxoplasma-positive individuals significantly more severe positive psychotic symptoms. No significant association observed antibody herpesviruses. Conclusions In infection an environmental factor contributing manifestation

参考文章(20)
Alison R. Yung, Lisa J. Phillips, Patrick D. McGorry, Colleen A. McFarlane, Shona Francey, Susan Harrigan, George C. Patton, Henry J. Jackson, Prediction of psychosis. A step towards indicated prevention of schizophrenia The British journal of psychiatry. Supplement. ,vol. 172, pp. 14- 20 ,(1998) , 10.1192/S0007125000297602
Alan S Brown, Patricia Cohen, Jill Harkavy-Friedman, Vicki Babulas, Dolores Malaspina, Jack M Gorman, Ezra S Susser, Prenatal rubella, premorbid abnormalities, and adult schizophrenia Biological Psychiatry. ,vol. 49, pp. 473- 486 ,(2001) , 10.1016/S0006-3223(01)01068-X
F. Markus Leweke, Christoph W. Gerth, Dagmar Koethe, Joachim Klosterk�tter, Inna Ruslanova, Bogdana Krivogorsky, E. Fuller Torrey, Robert H. Yolken, Antibodies to infectious agents in individuals with recent onset schizophrenia. European Archives of Psychiatry and Clinical Neuroscience. ,vol. 254, pp. 4- 8 ,(2004) , 10.1007/S00406-004-0481-6
John E. Overall, Donald R. Gorham, The Brief Psychiatric Rating Scale Psychological Reports. ,vol. 10, pp. 799- 812 ,(1962) , 10.2466/PR0.1962.10.3.799
W D Cubitt, A E Ades, C S Peckham, Evaluation of five commercial assays for screening antenatal sera for antibodies to Toxoplasma gondii. Journal of Clinical Pathology. ,vol. 45, pp. 435- 438 ,(1992) , 10.1136/JCP.45.5.435
Nancy C. Andreasen, Negative Symptoms in Schizophrenia Archives of General Psychiatry. ,vol. 39, pp. 784- 788 ,(1982) , 10.1001/ARCHPSYC.1982.04290070020005
E. F. Torrey, R. H. Yolken, Could Schizophrenia Be a Viral Zoonosis Transmitted From House Cats Schizophrenia Bulletin. ,vol. 21, pp. 167- 171 ,(1995) , 10.1093/SCHBUL/21.2.167
R. H. Yolken, S. Bachmann, I. Rouslanova, E. Lillehoj, G. Ford, E. F. Torrey, J. Schroeder, Antibodies to Toxoplasma gondii in individuals with first-episode schizophrenia. Clinical Infectious Diseases. ,vol. 32, pp. 842- 844 ,(2001) , 10.1086/319221
Alan S Brown, Catherine A Schaefer, Charles P Quesenberry Jr, Liyan Liu, Vicki P Babulas, Ezra S Susser, None, Maternal Exposure to Toxoplasmosis and Risk of Schizophrenia in Adult Offspring American Journal of Psychiatry. ,vol. 162, pp. 767- 773 ,(2005) , 10.1176/APPI.AJP.162.4.767
E. Fuller Torrey, Robert H. Yolken, Toxoplasma gondii and schizophrenia. Emerging Infectious Diseases. ,vol. 9, pp. 1375- 1380 ,(2003) , 10.3201/EID0911.030143