作者: G. Paul Amminger , Patrick D. McGorry , Gregor E. Berger , Darryl Wade , Alison R. Yung
DOI: 10.1016/J.BIOPSYCH.2006.09.034
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摘要: Background While there is evidence that some cases of schizophrenia may be associated with microbial infections, the role agents has not been investigated in people emerging psychosis. Methods Participants were 105 help seeking ultra-high risk individuals. Psychiatric measures included Brief Rating Scale and for Assessment Negative Symptoms. Serum IgG antibodies against human herpesviruses Toxoplasma gondii determined using immunoassay methods. Multiple linear regression adjustment age sex was applied to test associations between serum psychiatric measures. Results Higher levels Toxoplasma-positive individuals significantly more severe positive psychotic symptoms. No significant association observed antibody herpesviruses. Conclusions In infection an environmental factor contributing manifestation