Involvement of brain histamine in Δ9-tetrahydrocannabinol tolerance and withdrawal☆
作者： A.J.M. Verberne , M.R. Fennessy , S.J. Lewis , D.A. Taylor
DOI: 10.1016/0091-3057(85)90549-0
关键词:
摘要: Abstract The involvement of brain histamine (HA) in Δ 9 -tetrahydrocannabinol ( -THC) tolerance and dependence was studied rats. Rats treated for 5 days with -THC (2–6 mg/kg, IV) developed to the hypothermic effects drug. Tolerance also over day period decrease regional HA concentrations observed after an acute injection -THC. Administration tricyclic antidepressant drug clomipramine hydrochloride tolerant rats induced a withdrawal-like behavioural syndrome. Accompanying this behaviour fall midbrain, cortex, medulla oblongata/pons cerebellum. -THC, but not vehicle, prior challenge attenuated both intensity syndrome reductions concentration.
elsevier.com
sci-hub.se 参考文章(18)
Jacques Glowinski, Leslie L. Iversen, Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. Journal of Neurochemistry. ,vol. 13, pp. 655- 669 ,(1966) , 10.1111/J.1471-4159.1966.TB09873.X
S. J. Lewis, M. R. Fennessy, F. J. Laska, D. A. Taylor, A modified method for the isolation and determination of brain histamine using Bio-Rex 70 Inflammation Research. ,vol. 10, pp. 197- 206 ,(1980) , 10.1007/BF02025936
D. E. McMillan, W. L. Dewey, L. S. Harris, CHARACTERISTICS OF TETRAHYDROCANNABINOL TOLERANCE Annals of the New York Academy of Sciences. ,vol. 191, pp. 83- 99 ,(1971) , 10.1111/J.1749-6632.1971.TB13990.X
Joseph J. Schildkraut, Daniel H. Efron, The effects of Δ9-tetrahydrocannabinol on the metabolism of norepinephrine in rat brain Psychopharmacology. ,vol. 20, pp. 191- 196 ,(1971) , 10.1007/BF00404373
A. J. M. Verberne, D. A. Taylor, M. R. Fennessy, Withdrawal-like behaviour induced by inhibitors of biogenic amine reuptake in rats treated chronically with delta 9-tetrahydrocannabinol. Psychopharmacology. ,vol. 68, pp. 261- 267 ,(1980) , 10.1007/BF00428113
Michael J. Hosko, William T. Schmeling, Harold F. Hardman, Evidence for a caudal brainstem site of action for cannabinoid induced hypothermia. Brain Research Bulletin. ,vol. 6, pp. 251- 258 ,(1981) , 10.1016/S0361-9230(81)80055-X
M. Garbarg, G. Barbin, J. Feger, J.-C. Schwartz, Histaminergic pathway in rat brain evidenced by lesions of the medial forebrain bundle. Science. ,vol. 186, pp. 833- 835 ,(1974) , 10.1126/SCIENCE.186.4166.833
M.R. Fennessy, S.J. Lewis, D.A. Taylor, A.J.M. Verberne, delta 9-Tetrahydrocannabinol reduces brain regional histamine concentrations. British Journal of Pharmacology. ,vol. 78, pp. 452- 454 ,(1983) , 10.1111/J.1476-5381.1983.TB08804.X
M.R. FENNESSY, D.A. TAYLOR, THE EFFECT OF Δ9‐TETRA‐HYDROCANNABINOL ON BODY TEMPERATURE AND BRAIN AMINE CONCENTRATIONS IN THE RAT AT DIFFERENT AMBIENT TEMPERATURES British Journal of Pharmacology. ,vol. 60, pp. 65- 71 ,(1977) , 10.1111/J.1476-5381.1977.TB16748.X
D. A. TAYLOR, M. R. FENNESSY, Time‐course of the effects of chronic Δ9‐tetrahydrocannabinol on behaviour, body temperature, brain amines and withdrawal‐like behaviour in the rat Journal of Pharmacy and Pharmacology. ,vol. 34, pp. 240- 245 ,(2011) , 10.1111/J.2042-7158.1982.TB04235.X