Nuclear Overhauser Enhancement Mediated Chemical Exchange Saturation Transfer Imaging at 7 Tesla in Glioblastoma Patients

摘要: BACKGROUND AND PURPOSE Nuclear Overhauser Enhancement (NOE) mediated chemical exchange saturation transfer (CEST) is a novel magnetic resonance imaging (MRI) technique on the basis of between exchanging protons tissue proteins and bulk water. The purpose this study was to evaluate compare information provided by three dimensional NOE CEST at 7 Tesla (7T) standard MRI in glioblastoma patients. PATIENTS METHODS Twelve patients with newly diagnosed histologically proven were enrolled prospective ethics committee-approved study. contrast acquired modified three-dimensional gradient-echo sequence asymmetry analysis conducted 3.3 ppm (B1 = 0.7 µT) calculate magnetization ratio (MTR(asym)). Contrast enhanced T1 (CE-T1) T2-weighted images 3T used for data co-registration comparison. RESULTS Mean signal based MTR(asym) values over all significantly increased (p<0.001) CE-T1 tumor (-1.99 ± 1.22%), necrosis (-1.36 1.30%) peritumoral hyperintensities (PTCH) within T2 edema margins (-3.56 1.24%) compared contralateral normal appearing white matter (-8.38 1.19%). In (p 0.015) mean higher than PTCH. Extent surrounding hyperintensity smaller eight out 12 images, while four displayed equal size. patients, isolated high intensity regions (0.40 2.21%) that not discernible or images. CONCLUSION Imaging T provides additional structure displays cannot be Further research needed determine origin possible clinical applications such as therapy assessment biopsy planning.