Alterations of methylation of the tumor suppressor gene p53 : insights into potential mechanisms of arsenic carcinogenesis

摘要: Arsenic is a carcinogen to which alarmingly large numbers of people are chronically exposed (Tseng et al., 1968; US Environmental Protection Agency, 1980; Smith 1992). Human exposure arsenic has been documented in ecological and epidemiologic studies, there little question that such associated with elevated cancers Enterline 1995). Most disheartening, though, the fact unified cogent hypothesis for mechanism action as not advanced, factors govern individual susceptibility carcinogenesis known. Further, although we have comprehended how acts poison many years (Fowler, 1991), whether or this mode related its carcinogenicity unknown, cannot be directly tested given an animal model relevant human scenarios thoroughly validated.