Association between iron status and thyroid function in Nepalese children.

作者: Saroj Khatiwada , Basanta Gelal , Nirmal Baral , Madhab Lamsal

DOI: 10.1186/S13044-016-0031-0

关键词:

摘要: Deficiencies of iodine and iron may have adverse effect on thyroid function. This study was undertaken to investigate the association between status function in Nepalese children living hilly regions. A cross-sectional conducted among 227 school aged 6–12 years regions eastern Nepal. Urine blood samples were analyzed for urinary concentration, free thyroxine, triiodothyronine, stimulating hormone, hemoglobin, serum total binding capacity, percentage transferrin saturation calculated. The cohort comprised euthyroid (80.6 %, n = 183), overt hypothyroid (1.3 %, n = 3), subclinical (16.3 %, n = 37) hyperthyroid (1.8 %, n = 4) respectively. About 35.2 % (n = 80) anemic, 43.6 % (n = 99) deficient 19.8 % (n = 45) had excretion < 100 μg/L. Hypothyroidism (overt subclinical) common anemic children. relative risk having hypothyroidism 5.513 (95 % CI: 2.844−10.685, p < 0.001) 1.939 1.091-3.449, p = 0.023) respectively as compared non-anemic sufficient Thyroid hormone significant negative correlation with hemoglobin (r = −0.337, (r = −0.204, p = 0.002). dysfunction, deficiency anemia are In this cohort, poor

参考文章(34)
Baral N, Lamsal M, Koirala S, Koner Bc, Thyroid dysfunction in eastern Nepal. Southeast Asian Journal of Tropical Medicine and Public Health. ,vol. 33, pp. 638- 641 ,(2002)
Eric Elguero, Mohammad R Eshraghian, Seyed Ali Keshavarz, Mahmood Jalali, Kirsten B Simondon, Mohammad Hassan Eftekhari, The relationship between iron status and thyroid hormone concentration in iron-deficient adolescent Iranian girls. Asia Pacific Journal of Clinical Nutrition. ,vol. 15, pp. 50- 55 ,(2006)
Saroj Khatiwada, Basanta Gelal, Prem Raj Shakya, Madhab Lamsal, Nirmal Baral, Urinary Iodine Excretion among Nepalese School Children in Terai Region Indian Journal of Pediatrics. ,vol. 83, pp. 15- 17 ,(2016) , 10.1007/S12098-015-1755-X
Alexandra P. Bremner, Peter Feddema, David J. Joske, Peter J. Leedman, Peter C. O’Leary, John K. Olynyk, John P. Walsh, Significant association between thyroid hormones and erythrocyte indices in euthyroid subjects Clinical Endocrinology. ,vol. 76, pp. 304- 311 ,(2012) , 10.1111/J.1365-2265.2011.04228.X
S Khatiwada, B Gelal, N Baral, M Lamsal, S Singh, M K Tamang, R Kc, Iodized Salt Use and Salt Iodine Content among Household Salts from Six Districts of Eastern Nepal. Journal of Nepal Health Research Council. ,vol. 12, pp. 191- 194 ,(2014)
Saroj Khatiwada, Rajendra KC, Santosh Kumar Sah, Seraj Ahmed Khan, Rajendra Kumar Chaudhari, Nirmal Baral, Madhab Lamsal, Thyroid Dysfunction and Associated Risk Factors among Nepalese Diabetes Mellitus Patients International Journal of Endocrinology. ,vol. 2015, pp. 570198- 570198 ,(2015) , 10.1155/2015/570198
Umesh Kapil, Health consequences of iodine deficiency. Sultan Qaboos University Medical Journal. ,vol. 7, pp. 267- 272 ,(2007)
Sonja Y. Hess, Michael B. Zimmermann, Myrtha Arnold, Wolfgang Langhans, Richard F. Hurrell, Iron Deficiency Anemia Reduces Thyroid Peroxidase Activity in Rats Journal of Nutrition. ,vol. 132, pp. 1951- 1955 ,(2002) , 10.1093/JN/132.7.1951
Toshinori Ohashi, Mitsuo Yamaki, Chandrakant S Pandav, Madhu G Karmarkar, Minoru Irie, Simple Microplate Method for Determination of Urinary Iodine Clinical Chemistry. ,vol. 46, pp. 529- 536 ,(2000) , 10.1093/CLINCHEM/46.4.529
Mohammad Hassan Eft, Mohammad Reza Eshra, Hassan Mozaffari-, Navid Saadat, Farzad Shidfar, Effect of iron repletion and correction of iron deficiency on thyroid function in iron-deficient Iranian adolescent girls. Pakistan Journal of Biological Sciences. ,vol. 10, pp. 255- 260 ,(2007) , 10.3923/PJBS.2007.255.260