A Method of Producing Carcinoma in Upper Aerodigestive Tree and Esophagus of the Syrian Golden Hamster Using Wounding and Instillation of N-Methylnitrosourea
作者： Richard D. Estensen , W. Robert Anderson , Arthur R. Galbraith , Donna E. Hartle , Margaret M. Jordan
DOI: 10.1158/1055-9965.EPI-06-1075
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摘要: Details of a method for producing carcinoma the aerodigestive tree Syrian golden hamster and use this model to evaluate putative agents chemoprevention these carcinomas are described. The produces majority squamous trachea glottis that follow metaplasia respiratory epithelium. In addition, seen adenocarcinomas arising in glands tree. Squamous digestive epithelium arise primary These tumors have growth pattern differs from they grow invade without filling epithelial layer with tumor cells.
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