Interactions of Lanthanides with Tissues, Cells, and Cellular Organelles

摘要: Over 75 years ago, Mines (1910, 1911) described the inhibitory effect of lanthanide ions on beating perfused frogs’ hearts. Shortly thereafter, similar responses were noted for skeletal muscle (Hober and Spaeth, 1914). However, modern experimental use lanthanides in cellular biochemistry physiology originates with paper Lettvin et al. (1964). Drawing attention to ionic radii Ca2+ La3+, these authors suggested that La3+ should occupy Ca2+-binding sites nerve axons but, being higher valency, bind much more strongly than Ca2+. This observation anticipated detailed comparisons Ln3+ by bioinorganic chemists (Section 2.5). (1964) proposed would function as nerve-blocking agents. The subsequent confirmation this prediction (Takata al., 1966) led way widespread studies fluxes, especially regard their role excitation other stimulus-coupled responses. Much development area research stems from investigations Van Breeman, Weiss, colleagues cells. Reviews various aspects field have been written Weiss (1974), Mikkelsen (1976), Dos Remedios (1981).